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Probing the Flexibility of Large Conformational Changes in Protein Structures through Local Perturbations

Figure 5

Ensemble of the last conformation of the trajectories of perturbations induced by RIP for (A) TIM, (B) DHFR, (C) αLP, (D) ER, (E) HSP90.

Red corresponds to an RMSD deviation of 15 Å or more. These ensembles are used to generate the flexibility histograms.

doi: https://doi.org/10.1371/journal.pcbi.1000343.g005