Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling
Figure 7
(A) A heatmap depicts the data, untrained model (Figure 3B), and trained model time courses for MK2. (B) The regressed rule weights are plotted for the 12 candidate rules. The rules are indicated in tabular format; the first two rows describe the state of the inputs, TNF and time, and the last row is the output MK2 state. L and H represent low and high states, and E is the state describing the early response lag. Symbols above the plot show whether the rules were present (✓) or not applicable () in the untrained model.