Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling
Figure 6
Model prediction of C225 interference with TNF-stimulated signaling.
A heatmap depicts the experimental and FL-model predicted response of cells co-treated with 5 ng/mL of TNF and 10 µg/mL of C225 (an antibody that interferes with ligand binding to the EGF receptor), as compared to TNF alone. The model fitness without and with C225 are 2.9 and 2.6, respectively.