Systems Analysis of Bioenergetics and Growth of the Extreme Halophile Halobacterium salinarum
Figure 5
Predicted fluxome during exponential phase (t = 30) that maximizes energy production.
Yellow ellipses represent compounds that are taken up from the medium, while light-red ellipses represent those that are accumulated in the medium. Larger fluxes are drawn with thicker arrows. Black and red arrows correspond to qualitatively invariable and qualitatively variable (see main text) fluxes, respectively. Side reactants, for the most part, are not depicted in the figure. Yellow rounded boxes represent biochemical pathways. Metabolite abbreviations: 3dhq - 3-dehydroquinate, 5,10mtthf - 5,10-methylenetetrahydrofolate, 6pglcn - 6-phosphogluconate, ac-CoA - acetyl-CoA, Ala - alanine, Asn - asparagine, Asp - aspartate, asp4sa - aspartate 4-semialdehyde, Arg - arginine, Cys - cysteine, dkfrcp - 6-deoxy-5-ketofructose 1-phosphate, gal - galactose, gap - glyceraldehyde 3-phosphate, cho - chorismate, glc - glucose, Gly - glycine, glyc - glycerol, Glu - glutamate, Gln - glutamine, His - histidine, hmg-CoA - 3-hydroxy-3-methyl-glutaryl-CoA, ipdp - isopenteny diphosphate, Ile - isolecuine, Leu - leucine, Lys - lysine, Met - methionine, mev - mevalonate, Orn - ornithine, Phe - phenylalanine, Pro - proline, prop-CoA - propanoyl-CoA, prpp - 5-phosphoribosyl diphosphate, pyr - pyruvate, Ser - serine, shk - shikimate, thf - tetrahydrofolate, Thr - threonine, Trp - tryptophan, Tyr - tyrosine, uppg-III - uroporphyrinogen III, Val - valine.