Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full-Length Dimer
Figure 8
Time evolution of the tilt angle between the two N-Terminal helices 1.
The figure represents the time evolution of the cosine of the dihedral angle between the axis helix 1 from one protomer and the axis of the second helix 1 from the other protomer. In the ADP simulation a clear variation of the cosine of the angle can be observed, identifying the increase of the tilt and the unwrapping of the helices described in the text.