Computational Model of the Insect Pheromone Transduction Cascade
Figure 10
Kinetics of the major currents and SP at different pheromone uptakes.
Uptakes separated by 2 log units from low to high, (A) 1.78×10−5, (B) 1.78×10−3, (C) 0.178 and (D) 17.8 µM/s. Insets show the rise of each current during the first 0.5 s (top) or 0.3 s (bottom). DAG-gated current Icat (dashed blue) is the main depolarizing current at low dose (A). Ca2+-gated current ICl (solid green) takes over the major role at high doses (C and D). The kinetic response of the repolarizing current IK (dashed red) is close to that of Icat at low dose (A) and close to that of ICl at high doses (C and D). As shown in the insets, IK closely follows Icat at the beginning of the rising phase.