Probabilistic Interaction Network of Evidence Algorithm and its Application to Complete Labeling of Peak Lists from Protein NMR Spectroscopy
Figure 6
Graphical network for backbone chemical shift assignments.
Overlapping tripeptides (triplet residue) are evaluated. The weights on the edges are derived from amino acid typing, secondary structures, connectivity experiments, and possible outlier assignments. According to the statistical physics model described in the text, application of the belief propagation algorithm yields the marginal probabilities for backbone assignments.