Mechanical Network in Titin Immunoglobulin from Force Distribution Analysis
Figure 6
Comparison of in silico rupture forces for the A'G strand with experimental data.
(A) Our simulations predict decreased stability of the A'G strand for 5 residues near the A'G strand, rendering them interesting targets for further experimental studies. The figure shows these residues mapped as sticks on the I27 structure. F21, L84 and V71 are colored blue, the experimentally validated V13 and V86 are colored red. (B) Changes in rupture force from experiment and simulation plotted against each other. The line shows a fit of the data to a linear model. Experimental data for a pulling speed of 10 nm s−1 were extracted from Figure 3, Best et al. 2003 [14].