< Back to Article

Mechanical Network in Titin Immunoglobulin from Force Distribution Analysis

Figure 5

Forces needed for transition into the intermediate state measured for a selected set of in silico mutations.

(A) values for the mutated residues sorted in descending order. The nine residues with highest , for which decreased rupture forces are expected, are colored gray. (B) Rupture forces observed for transition into the intermediate. The majority of the nine residues with highest shows a significant decrease in rupture forces comparing to the wild-type (WT), while residues with significantly lower show less impact onto rupture forces upon mutation. The overall decrease comparing to the WT and to the six negative controls is statistically significant (p<0.01 and p<0.03, respectively, student's t-test on cumulative rupture force data. For individual p-values, see Table S1).

doi: https://doi.org/10.1371/journal.pcbi.1000306.g005