Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins
Figure 6
Statistics of quaternary nodes and rigid-body motions in global communication networks.
(A) Rigid-body size versus protein size (number of residues) for all rigid bodies in the global communication networks (GCNs) of all proteins in the allosteric benchmark set [29]. A point at (2800, 1200) is excluded for clarity. (B) histogram of rotation angle for all edges between all rigid bodies in these GCNs. (C) histogram of interfacial contact rearrangement fCR for all edges between rigid bodies in these GCNs. For constructing the histograms in (B) and (C), each edge in each GCN is weighted by the inverse of the number of asymmetric units in the protein to normalize for multiple symmetry-related motions in some oligomers. Bin labels refer to the upper bound of the bin. Only edges between rigid bodies both of which comprise 30 or more residues are included in the histograms.