Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins
Figure 5
Proposed individual substrate-effector “pathways” in the PFK GCN.
The complete GCN of PFK is shown in Figure 4. We define a “pathway” between a substrate and an effector site in the GCN as the shortest loop containing them, plus any cross-interactions among members of that loop. If two or more loops are tied for the shortest, the union of all such loops constitutes the pathway. This pathway is the smallest (by number of nodes) subset of the GCN required to form an allosteric unit containing the two sites. Four symmetrically unique paths emanating from the effector site of chain A are shown.