Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins
Figure 3
Relationship of tertiary and quaternary communication in PFK.
(A) Contact rearrangement network (CRN) of phosphofructokinase. As described previously [12], nodes are protein residues (circles), effector sites (diamonds), and substrate sites (squares), and edges are contact rearrangements between protein residues and protein-ligand site contacts. Two of four symmetry-related contact rearrangement clusters are shown for clarity. Each protein residue is colored according to the color in Figure 2B of the quaternary node to which that residue belongs. (B) Quaternary network of Figure 2B, with each edge colored according to the CRN cluster (if any) to which the corresponding quaternary interface contributes. A red edge indicates that a quaternary interface contributes to more than one CRN cluster. A quaternary interface contributes to a CRN cluster if the CRN cluster contains two or more contact rearrangements that cross the quaternary interface.