Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins
Figure 1
Allosteric coupling via quaternary motions.
In this sample graph, circular nodes represent “rigid body” groups of residues that move collectively, and rectangular nodes represent ligands. Circular node area is proportional to physical size in number of residues. Edges represent motions between physically contacting rigid bodies. A grey dashed line marks the boundary of the allosteric unit.