Model-Based Therapeutic Correction of Hypothalamic-Pituitary-Adrenal Axis Dysfunction
Figure 5
Balancing intensity and duration of treatment.
Diagram of the minimal perturbation in normalized circulating cortisol u(t) as a function of duration of treatment. In one extreme instance the perturbation in cortisol would be so small that no treatment would be effective regardless of how much treatment prolonged. Conversely an excessively short treatment would also be ineffective regardless of the intensity of cortisol reduction.