Astrocytic Mechanisms Explaining Neural-Activity-Induced Shrinkage of Extraneuronal Space
Figure 2
Distribution of volume shrinkage and the potassium-volume shrinkage relation for different models.
Left panels: Normalised histograms of the distributions of relative ECS volume shrinkage (in %) for the five model configurations (mc1–mc5). The results were obtained by repeated numerical solution of steady state equations and only those parameter sets that satisfied the imposed ion concentrations constraints were used (see Methods). Right panels: Corresponding scatter plots of excited state relative shrinkage and potassium concentrations using the same data as in the left panels. Since the upper limit of the shown relative shrinkage and the lower limit of the shown [K+]o are set to 40% and 5 mM, respectively, some of the data are not displayed. Best linear fits are shown, and the corresponding slopes are 1.97, 1.70, 3.11, 2.74 and 4.08, respectively. Moreover, for reasons of visualization only 2% of the data are depicted.