An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcription Inhibitors
Figure 4
The computed probability of strand termination for an AZT and 3TC combination.
Computed probabilities are shown for AZT-TP alone (at 0.5 µM), 3TC-TP alone (at 0.1 µM) and the combination of both drugs at those concentrations (solid bars). The error bars represent standard deviations from 10 repeated sets of 1000 simulations. Also shown is the predicted probability of strand termination for the combined drugs (hatched bar) with the assumption of no interaction between the two drugs, calculated from the equation given in the text.