Deterministic Mechanical Model of T-Killer Cell Polarization Reproduces the Wandering of Aim between Simultaneously Engaged Targets
Figure 7
Oscillations of the centrosome between two synaptic areas.
(A) Graphs of the model cell structure. The angle between the two synaptic planes is indicated by the red arc and equals 144° in this simulation. Pulling force density, 40 pN/µm; microtubule length, 16 µm; effective cytoplasm viscosity, 2 pN s/µm2. (B) Trajectories of the centrosome predicted for the indicated angles between the two synaptic planes. An excerpt from the experimental trajectory extracted from the supplementary video to the cited paper [4] is also shown (dashed). The illustration in (A) corresponds to the red theoretical curve. Pulling force density, 40 pN/µm; microtubule length, 16 µm; effective cytoplasm viscosity, 2 pN s/µm2.