State Based Model of Long-Term Potentiation and Synaptic Tagging and Capture
Figure 4
Each diagram represents the state diagram for the model, and the the area of the circle around each state indicates the proportion of synapses occupying that state. (A) A single population of synapses is given weak HFS at . The stimulus results in a transient movement of synapses into the e-LTP state, followed by decay back to the initial state. (B) Multiple populations exhibiting synaptic tagging, capture and cross-capture. One population is given strong HFS at
. Synapses initially move into the e-LTP state, in which a tag is present, before moving into the
state via the eventual capture of PRPs. A second population is given weak HFS at
. Most of these synapses move swiftly into the
state once the stimulus is given; PRPs are already available as a result of the stimulus to Pop. 1, so capture occurs as soon as tag formation is complete. A third population is given weak LFS at
. Most of these synapses move swiftly into the
state once the stimulus is given; an LTD tag is set, and this can immediately “cross-capture”
proteins that have been synthesized and diffused as a result of the stimulus to Pop. 1.