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State Based Model of Long-Term Potentiation and Synaptic Tagging and Capture

Figure 3

Long-term potentiation and depression in the model.

(A) Weak HFS to population 1 at time results in e-LTP of that population. The increase in weight to about 150% lasts about 90 minutes. Population 2 is a “control pathway”, that has only test stimulation (to measure its strength) but no tetanic stimulus applied to it. Apart from the fluctuations its weight is stable. (B) Strong HFS to Pop. 1 at results in of that population. The control population is not affected. (C) Weak HFS to Pop. 1 at results in e-LTD of that population. (D) Strong LFS to Pop. 1 at results in .

doi: https://doi.org/10.1371/journal.pcbi.1000259.g003