Questioning the Ubiquity of Neofunctionalization
Figure 10
Underestimating the interaction conservation rate (equivalently, overestimating the interaction loss rate).
The conservation rate is the number of shared interacting partners divided by the total number of partners. (A) Gene 1 is duplicated to create paralogous pair 1 & 2. The true conservation rate is . (B) A neighbor of the paralogous pair duplicates and loses a redundant interaction. (C) The network as observed. The paralogous conservation rate of 1 & 2 is erroneously underestimated to be
. Equivalently, the true loss rate of
is overestimated to be
.