Questioning the Ubiquity of Neofunctionalization
Figure 9
The clustering coefficient of networks featuring simple duplication, neofunctionalization, subfunctionalization, and homomeric duplication.
Each plot shows the clustering coefficient for different probabilities of a gene duplicate losing a redundant interaction (i.e., different levels of subfunctionalization). Lines are grouped into pairs by color. A solid line is a model with a specific parameter, and a dashed line of the same color is the model's random equivalent (see Methods). The black line pairs represent simple duplication and subfunctionalization (i.e., no neofunctionalization or homomeric duplication) and are therefore identical in both plots. (A) The Solé et al. model which includes neofunctionalization [7]. (B) Homomeric duplication as found in the Vázquez et al. model [32].