Malleable Machines in Transcription Regulation: The Mediator Complex
Figure 5
Schematic representation of the Mediator complex: Head (orange), Middle (green), Tail (yellow), CDK (blue).
Subunits with higher than 50% average overall disorder (Med2, Med3 in Tail; Med9, Med19, Med26 in Middle and Med8 in Head) or subunits containing intrinsically disordered regions longer than 100 residues (Med12, Med13 of the CDK, Med1, Med9, Med26 of the Middle and Med15 of the Tail) in either Saccharomyces cerevisiae or in Homo sapiens are displayed by darker colors. Med19 and Med26 was assigned to the Middle module according to reference [80].