Malleable Machines in Transcription Regulation: The Mediator Complex
Figure 3
Amino acid compositions, relative to the set of globular proteins, of the Mediator (black), and its modules, Head (orange), Middle (green) and Tail (yellow) CDK (blue) in Saccharomyces cerevisiae (A) and in Homo sapiens (B).
Compositional profiling of intrinsically disordered proteins from the DisProt database is shown for comparison (red). The arrangement of the amino acids is by peak height for the set of disordered proteins from DisProt [29]. Confidence intervals were estimated using per-protein bootstrapping with 1,000 iterations.