Dynamic Correlation between Intrahost HIV-1 Quasispecies Evolution and Disease Progression
Figure 6
Dynamics of divergence and diversity with emergence of X4 viruses.
Dynamics of divergence and diversity when imposing a greater level of fitness for certain types of viruses which emerge and persist, for example, by acquiring X4 tropism. The X4 viruses appear at d = 50 with greater level of fitness Fhigh = 1.5 in comparison to R5 viruses with fitness F = 1. The fraction of X4 viruses out of the total virus population with d≥50 is given by α. The rapid transient increases both in divergence and diversity upon the emergence of X4 viruses are observed. The scale factor for the divergence is 500, that for the diversity is 100, and M(d) = 0.5 for all d.