Spontaneous Reaction Silencing in Metabolic Optimization
Figure 2
Number of active and inactive reactions in the metabolic networks of H. pylori, S. aureus, E. coli, and S. cerevisiae.
For each organism, the bars correspond to a typical non-optimal state (top), a growth-maximizing state (middle), and a state with the minimum number of active reactions required for growth (bottom), which was estimated using the algorithm described in Materials and Methods. The error bar represents the upper and lower theoretical bounds, given by Eq. (3), on the number of active reactions in any growth-maximizing state. The breakdown of inactive reactions and their color coding are the same as in Figure 1. All results are obtained using glucose minimal media (Materials and Methods) and are further detailed in Tables 2 and 3.