Quantification of Local Morphodynamics and Local GTPase Activity by Edge Evolution Tracking
Figure 2
GTPase cascades involved in morphological regulation and cytoskeleton organization.
Various upstream signals trigger the activation of Cdc42, Rac, and Rho GTPases and induce morphological and cytoskeletal changes such as formation of filopodia, lamellipodia, and stress fibers, respectively. The ratio of the inactive GDP-bound state to active GTP-bound state is regulated by guanine nucleotide exchange factors (GEFs) and the GTPase-activating proteins (GAPs). Many studies have shown crosstalk between these GTPases; however, direct links between these GTPases are still to be clarified.