Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals
Figure 4
Our model predicts distinct nucleosome organizations around transcription start sites.
Shown is the average nucleosome organization around transcription start sites of four sets of genes that were reported in [5] by clustering their measured nucleosome occupancy profiles. One of the four clusters reported in [5] corresponds to promoters that lack a significant nucleosome depleted region (cluster 1; red line in plots). The other three clusters have a clear nucleosome depleted region in their promoters, and are also reported in [5] as enriched for protein biosynthesis (cluster 2; green line), ribosome biogenesis (cluster 3; blue line), and protein modification (cluster 4; cyan line). The average nucleosome occupancy is shown from the original data of [5] (top) that was used for the clustering, and for our data (middle), as well as for the predicted occupancy of the nucleosome positioning model that we developed here (bottom).