Transmembrane Topology and Signal Peptide Prediction Using Dynamic Bayesian Networks
Figure 9
Philius topology prediction for the human presenilin protein as shown on the YRC web-page.
The diagram shows the nine membrane-spanning regions as vertical cylinders, and the cytoplasmic and non-cytoplasmic segments as horizontal bars. Each segment is colored according to type and shaded according to the confidence score. The seventh membrane-helix is missed by many topology predictors and is assigned a relatively low confidence score by Philius and as such is shaded gray. Because of this one low-confidence membrane segment, the location of the C-terminus is less confidently assigned than the location of the N-terminus. On the YRC web page, this diagram is accompanied by the type confidence and topology confidence, as well as a copy of the protein sequence, color coded by segment type. Placing the mouse over any part of the topology diagram or the color-coded sequence will produce a pop-up showing the segment type, confidence, and boundary locations.