The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation
Figure 6
Calcium influx in response to tetanic stimulation.
(A,B) LTP was induced by 100 Hz tetanic stimulation with a duration of 1 sec. The postsynaptic voltage (A) and stochastic glutamate release (B) were both modulated synaptic facilitation and depression. (C–F) Example postsynaptic calcium concentration traces (C,D) from simulations with 5 NR2A-containing or 5 NR2B-containing NMDARs, and mean calcium concentration in the spine in for three different numbers of receptors (E,F) show that NR2A-NMDARs drove spine calcium concentration much higher, per receptor, than did NR2B-NMDARs.