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Organization of Excitable Dynamics in Hierarchical Biological Networks

Figure 1

Basic graph models representing different combinations of both modular and hub characteristics.

The degree of a node (as an example of a hub characteristic) is indicated by its size, while the grouping of the nodes reveals the modular structure. (A) The Erdös-Rényi (ER) random graph lacks both hubs and modules; (B) the scale-free Barabási-Albert (BA) graph displays a center of interlinked hubs only; the (C) random modular graph and the (D) scale-free modular graph consist of planarly linked modules, which are composed of smaller ER graph and BA graphs, respectively. The hubs in the BA graph version are distributed among the modules. The hierarchical graphs in (E) and (F) are featured by modules consisting of modules. In contrast to the hierarchical cluster graph in (E), the hierarchical scale-free graph (F) is additionally characterized by a hierarchical structure of hubs with one hub dominating the center.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1000190.g001