Natural Selection Fails to Optimize Mutation Rates for Long-Term Adaptation on Rugged Fitness Landscapes
Figure 2
Evolutionary trajectories for fitness and mutation rate on a complex fitness landscape.
(A) Evolution of average log-fitness±1 s.e.m. for treatments with the mutation rate fixed at Uopt = 4.641 (black) and for treatments with variable mutation rates starting at either 10 (red) or 10−3 (blue). (B) Evolution of average log genomic mutation rate±1 s.e.m. for treatments with variable mutation rates starting at either 10 (red) or 10−3 (blue). The black line indicates the mutation rate that had produced the highest average fitness for that time point.