Protein Meta-Functional Signatures from Combining Sequence, Structure, Evolution, and Amino Acid Property Information
Figure 2
Performance comparison of the MFS method, the SeqonlyMFS method (HMM_rel_ent+SSR+AAType), the Evolutionary Trace method, and the ConSurf method with the Thornton and Lovell datasets.
Only proteins for which both the Evolutionary Trace and ConSurf methods are able to give predictions are used in the comparison. Four measures are used to compare the performance, including: ROC scores, the precision when sensitivity threshold is set at 20%, the false positive rate when sensitivity threshold is set at 20% and the top-10 hits. ET is only used in the ROC score computation but not in other comparative analysis, since it gives many tied scores for top-scoring residues. Both the MFS and SeqonlyMFS methods have better performances than methods that use only one type of information.