Identifying the Important HIV-1 Recombination Breakpoints
Figure 4
Implementation of the recombination model.
Comparison of model-predicted breakpoints (horizontal lines) with breakpoint locations from HIV-1 recombinants (vertical bars) [26] from the HIV Sequence Database. White bars indicate where the number of breakpoints for the global data is significantly higher than the prediction for the region, light grey bars indicate where the global data falls within the prediction, while dark grey indicates where the global data is significantly lower than the model prediction. The error bars on the model-predicted values represent 1.645×standard error to include 90% of the distribution. The normalised frequency data (y-axis) have been divided into bins of size 400 nucleotides (x-axis). Below the x-axis, the various genomic regions of the HIV-1 genome are displayed. Note, positioning of genes is relative to a gap-stripped sequence alignment.