Insights into Protein–DNA Interactions through Structure Network Analysis
Figure 7
Interaction of the transcription factor Max (1hlo) of the zipper-type group (basic-helix-loop-helix-zipper) with DNA.
The Max transcription factor, which belongs to the Helix-Loop-Helix Zipper family, has a dimerization domain and a DNA binding domain (center). The DNA binding domain shows the presence of symmetric P-p (yellow) and asymmetric P-B clusters (blue) (upper and lower). The cluster compositions are given (single letter code for nodes: upper case for amino acids and lower case for nucleotides). The cluster compositions for other proteins are given in Table S2. There is a marked absence of P-S clusters in the recognition of DNA by this zipper protein.