Insights into Protein–DNA Interactions through Structure Network Analysis
Figure 4
A protein-base (P-B) hub in TATA box binding protein (TBP/DNA).
An amino acid interacts with four different bases to form a P-B hub. In the TATA box binding protein (1tgh) the position of a P-B hub Phe193 (at MEC 3%) is shown. This hub (blue) interacts mainly with bases from four different nucleotides (red) T115, A116, T109, and A110.