Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress
Figure 4
Oxidative stress-mediated induction in Sod1, Nqo1 and Als2 mRNA.
Increases in expression of Sod, Nqo1, and Als2 mRNA only in Nrf2+/+ (WT) CD-1 mice but not Nrf2−/− (NO) mice following cigarette smoke (CS) exposure. This figure depicts mean (n = 3) mRNA expression from the microarrays on Nrf2+/+ air-exposed (WTAir), Nrf2+/+ CS-exposed (WTCS), Nrf2−/− air-exposed (NOAir) and Nrf2−/− CS-exposed (NOCS). Results shown suggest regulation of these genes by Nrf2.