Classifying RNA-Binding Proteins Based on Electrostatic Properties
Figure 1
The overlap between the largest positive patch and the real RNA-binding interface in three different RBPs.
(A) L1 ribosomal protein (1mzp), (B) rotavirus nonstructural protein (1knz), and (C) tymovirus coat and capsid binding protein (1ddl). The blue region represents the largest positive patch, yellow is the real binding interface (calculated as described in the Materials and Methods section), and green denotes the overlap between the extracted patch and the real interface. Notably, in (A) there is a large overlap (0.9) between the positive patch and the interface, while a very small overlap (0.05) was observed in (C).