Protein Complex Evolution Does Not Involve Extensive Network Rewiring
Figure 2
The eIF3 complexes in yeast (yellow) and human (green) are depicted in a network with similar topography relevant to the orthologs (connected by red dotted lines). Although the eIF3 complex in human has expanded compared to yeast, all yeast proteins still have orthologs in the human eIF3 complex. Modification of the complex seems to have been mainly through the acquisition of new proteins.