Allosteric Communication in Myosin V: From Small Conformational Changes to Large Directed Movements
Figure 8
Cα-RMS deviation of the NMSM post-rigor conformation from the “target” (i.e., the X-ray post-rigor conformation after energy minimization) as a function of the number of low-frequency rigor modes included in the optimal superposition.
The rigor modes were first sorted according to their rigor-like/post-rigor involvement coefficients and then combined as described in Materials and Methods. Only 14 modes are sufficient to obtain a NMSM conformation that is at 1.5 Å RMSD from the target structure. The mode indexes of these 14 highly involved modes are indicated.