Regulatory Control and the Costs and Benefits of Biochemical Noise
Figure 4
The Optimal Design of the lac Regulatory Network Is Determined by the lac Repressor Copy Number and the Repressor–Lactose Binding Constant.
Contour plot of the growth rate as a function of the repressor copy number X and repressor-lactose binding constant KD. The weighting of the lactose levels is nonuniform. Lower binding constants allow for higher optimal growth rates at lower optimal expression levels for the repressor.