Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions
Figure 6
AF-2 Surface Motions in PPARγ and ERα Complexes.
Similar to Figure 4, the active-capable PPARγ-RXR heterodimer and ERα homodimer complexes exhibit correlated motions in their AF-2 surfaces during MD trajectories (A, C), while inactive states of both receptors exhibit reduced AF-2 surface correlation (B, D).