Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions
Figure 4
Correlated AF-2 Domain Motions in the PXR-RXR Heterotetramer.
Vectors describing the motions of PXR LBD α-helices from the heterotetramer (A) and heterodimer (B) simulations show the active-capable heterotetramer PXR LBD exhibits more overall correlated motion as well as correlation between AF-2 surface helices. Each helix eigenvector (shown by an arrow) is the sum of the α-carbon eigenvectors in that helix. All arrows were generated using the same scalar magnifications of motion vectors and are presented on the same scale. As such, they represent relative, rather than absolute, movements.