Unraveling Protein Networks with Power Graph Analysis
Figure 8
Examples of Occurrences of Bicliques in Gene Regulatory Networks and Homology Networks.
Bicliques can occur in regulatory networks due to two reasons: some transcription factors operate within complexes–combinatorial regulation–and regulatory motifs in promoter regions can be shared and repeated for different genes. In the case of homology networks, proteins sharing a sequence region of high similarity–i.e. a domain–induce cliques. Bicliques are similarly induced between sub-groups of similar proteins due additional region of sequence similarity.