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Unraveling Protein Networks with Power Graph Analysis

Figure 6

Stars, Bicliques, and Cliques Counts as Obtained through Power Graph Analysis.

The area of each disc is proportional to the logarithm of the number of corresponding cliques (diagonal) and bicliques (non-diagonal). Stars are found along the first column or row. For example, there are 11 bicliques between two nodes and 4 nodes, and 34 bicliques of 6 nodes. The diagram is symmetric along the diagonal. Protein interaction networks from Gavin et al. (red) compared to corresponding rewired networks (blue). The high z-score (242) can be explained by significant abundance of cliques and bicliques compared to a random null-model obtained through rewiring. Note that despite the fact that the number of edges is constant, the total count of cliques, bicliques, and stars, is not necessarily constant.

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1000108.g006