Local Function Conservation in Sequence and Structure Space
Figure 6
On Experimental Annotation Data Only.
Comparing similarity scores to raw and combined function conservation scores. ROC analysis on a reduced high quality data set containing only experimental annotation data (evidence codes IDA, IEP, IGI, IMP, IPI) for 629 proteins. The black curve displays the average ROC curve for the four similarity measures (CE, TM, LP, GP); the boxplots are an estimate of the observed spread. The green curve corresponds to the average of the four raw function conservation scores. The ROC performance of selective and consensus combination is shown with the violet and blue curves, respectively.