Circadian Phase Resetting via Single and Multiple Control Targets
Figure 1
Circadian phase response behavior.
Phase response curves traditionally characterize the light pulse to induced phase mapping of the input admitted to a free-running circadian oscillator. Here, phase response dynamics of the four system parameters exhibiting greatest state sensitivity is depicted: νs (mRNA transcription), νm (mRNA degradation), ks (protein translation), and νd (protein degradation). The x-axis denotes the time at which the 2 hour pulse is given (where CT0 reflects dawn and CT12 dusk), and the y-axis describes the induced phase shift. A positive shift reflects a phase advance. Since light targets TIM specific protein degradation, νdT, the light-based PRC of the Drosophila model is represented via the dash-dotted line.