Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins
Figure 6
Relation between first passage time statistics and signal duration.
(A) Trajectories of x(t) on a semi-log plot. The abscissa represents time scaled by the characteristics time τ. Trajectories for three values of β are shown: β = 0.06 (blue), β = 0.8 (green), and β = 1.0 (red). kφ = 5 for each curve. Smaller values of β result in larger values of x(t) at longer times. (B) Values of signal duration as a function of β for different choices of threshold, T (defined in text); values of T are provided in the legend. For small values of T, β<1 (i.e., the presence of scaffolds) markedly increases signal duration.