Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins
Figure 3
Scaffold proteins allow for signals to be distributed over many time scales.
Variation of the survival probability with time scaled to characteristic time scales, τ. (A) S(t/τ) (on a semi-logarithmic scale) for different values of ζ. Values of ζ are given in the legend. Large deviations of exponential decay are observed near the optimal value of ζ (ζ = 1, red). (B) Survival probabilities were fit to a stretched exponential function (). Values of stretching exponent β as a function of scaffold density ζ are shown. Two cases are considered: (1) kinases can be activated only while bound to a scaffold (red) and (2) kinases can be activated while in solution and bound to a scaffold (blue). β deviates most from a purely an exponential (β = 1) at the optimal value of scaffold density (ζ = 1) in both cases.