Astrocytes Optimize the Synaptic Transmission of Information
Figure 4
Presynaptic [Ca2+] in response to 20 Hz stimulus without (top panel) and with (center panel) feedback from the astrocyte.
Opening of the voltage gated [Ca2+] channels due to an action potential gives rise to a [Ca2+] pulse that lasts 1.25 ms in our model. The y-axes have been normalized by [Ca2+] required to generate a release probability of P≈0.2 (300 µM for the Bertram, Sherman, and Stanley model [26]). (Bottom panel) Intracellular astrocytic [Ca2+] response in the astrocyte to 20 Hz of neuronal firing.