Electrotonic Signals along Intracellular Membranes May Interconnect Dendritic Spines and Nucleus
Figure 6
VE can be generated by a wide range of parameters.
One-dimensional mapping (i.e. one parameter at a time) of the fraction of the non-conductive cross-section (N) and the fraction of the ER cross-section of the total cross-section (E). All other parameters followed the default parameters (Table 2). VE amplitude is presented as percent of the EPSP amplitude at the position of the VE peak (nVE). Note that E and N describe each a fraction of the total cross-section, therefore their range is limited by: {N+E≤1}. (A) Levels of nVE-peaks are presented against different N (red trace) or E (blue trace) values. (B) The positions of the VE-peak are plotted against different N (red trace) or E (blue trace). (C,D) VE patterns are sampled across the range of E and N, tested. Traces generated with parameters above or below the default values are presented in blue or red, respectively. (E) Amplitude and position of the VE-peaks are presented against different m values. The red trace represents amplitude (nVE units). The Blue trace represents the position (λ units). Gray dashed lines mark the amplitude and position of the default value (m = 1). (F) VE patterns are sampled across the range of m, tested. Traces generated with m above or below the default value are presented in blue or red, respectively.